Human FKBP6 protein (Recombinant) (N-His) (STJP010728)

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STJP010728
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FKBP6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FKBP6
Gene ID: 8468
Uniprot ID: FKBP6_HUMAN
Immunogen Region: Ser20-Ser327
Immunogen: Homo sapiens (Human)
Function Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
Protein Name Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6
Inactive Ppiase Fkbp6
36 Kda Fk506-Binding Protein
36 Kda Fkbp
Fkbp-36
Fk506-Binding Protein 6
Fkbp-6
Immunophilin Fkbp36
Database Links Reactome: R-HSA-1221632
Reactome: R-HSA-5601884
Cellular Localisation Cytoplasm
Nucleus
In Spermatocytes
It Colocalizes With Piwil1 In Large Cytoplasmic Granules
Does Not Localize To The Synaptonemal Complex
Alternative Protein Names Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 protein
Inactive Ppiase Fkbp6 protein
36 Kda Fk506-Binding Protein protein
36 Kda Fkbp protein
Fkbp-36 protein
Fk506-Binding Protein 6 protein
Fkbp-6 protein
Immunophilin Fkbp36 protein
FKBP6 protein
FKBP36 protein

Information sourced from Uniprot.org

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