Human FKBP52/FKBP4 protein (Recombinant) (His-Tag) (STJP016450)

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STJP016450
€132.60 - €642.60
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FKBP52/FKBP4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity: Specific activity is > 700nmol/min/mg, and is defined as the amount of cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.
Gene Symbol: FKBP4
Gene ID: 2288
Uniprot ID: FKBP4_HUMAN
Immunogen Region: 1-459aa
Accession Number: NP_002005.1
Immunogen: Human
Immunogen Sequence: MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD KLFDQRELRF EIGEGENLDL PYGLER
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylation by CK2 results in loss of HSP90 binding activity.
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4
Ppiase Fkbp4
51 Kda Fk506-Binding Protein
Fkbp51
52 Kda Fk506-Binding Protein
52 Kda Fkbp
Fkbp-52
59 Kda Immunophilin
P59
Fk506-Binding Protein 4
Fkbp-4
Fkbp59
Hsp-Binding Immunophilin
Hbi
Immunophilin Fkbp52
Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed
Database Links Reactome: R-HSA-3371497
Reactome: R-HSA-3371568
Reactome: R-HSA-8939211
Reactome: R-HSA-9018519
Reactome: R-HSA-9679191
Cellular Localisation Cytoplasm
Cytosol
Mitochondrion
Nucleus
Cytoskeleton
Cell Projection
Axon
Shuttles From Mitochondria To Nucleus
Co-Localizes In Mitochondria With The Glucocorticoid Receptor
Colocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons
Alternative Protein Names Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 protein
Ppiase Fkbp4 protein
51 Kda Fk506-Binding Protein protein
Fkbp51 protein
52 Kda Fk506-Binding Protein protein
52 Kda Fkbp protein
Fkbp-52 protein
59 Kda Immunophilin protein
P59 protein
Fk506-Binding Protein 4 protein
Fkbp-4 protein
Fkbp59 protein
Hsp-Binding Immunophilin protein
Hbi protein
Immunophilin Fkbp52 protein
Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed protein
FKBP4 protein
FKBP52 protein

Information sourced from Uniprot.org

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