Human FKBP36/FKBP6 protein (Recombinant) (His-Tag) (STJP016700)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FKBP36/FKBP6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% Glycerol, 1mM EDTA, 0.2M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 190nmol/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAPF-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
Target Information
| Gene Symbol | FKBP6 |
| Gene ID | 8468 |
| Uniprot ID | FKBP6_HUMAN |
| Accession Number | NP_003593.3 |
| Immunogen | Human |
| Immunogen Region | 1-327aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |
| Function | Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. |
| Protein Name | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6Inactive Ppiase Fkbp636 Kda Fk506-Binding Protein36 Kda FkbpFkbp-36Fk506-Binding Protein 6Fkbp-6Immunophilin Fkbp36 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmNucleusIn SpermatocytesIt Colocalizes With Piwil1 In Large Cytoplasmic GranulesDoes Not Localize To The Synaptonemal Complex |
| Alternative Protein Names | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 proteinInactive Ppiase Fkbp6 protein36 Kda Fk506-Binding Protein protein36 Kda Fkbp proteinFkbp-36 proteinFk506-Binding Protein 6 proteinFkbp-6 proteinImmunophilin Fkbp36 proteinFKBP6 proteinFKBP36 protein |
Information sourced from Uniprot.org