| Host: |
E.coli |
| Applications: |
SDS-PAGE/Enzyme Activity |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Recombinant-Human FKBP12/FKBP1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: |
Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 1mM DTT, 10% Glycerol |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
< 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: |
Specific activity is > 800nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin. |
| Gene Symbol: |
FKBP1A |
| Gene ID: |
2280 |
| Uniprot ID: |
FKB1A_HUMAN |
| Immunogen Region: |
1-108aa |
| Accession Number: |
NP_463460.1 |
| Immunogen: |
Human |
| Immunogen Sequence: |
MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE |
| Function | Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1aPpiase Fkbp1a12 Kda Fk506-Binding Protein12 Kda FkbpFkbp-12Calstabin-1Fk506-Binding Protein 1aFkbp-1aImmunophilin Fkbp12Rotamase |
| Database Links | Reactome: R-HSA-166208Reactome: R-HSA-2025928Reactome: R-HSA-2173789Reactome: R-HSA-2173791Reactome: R-HSA-3656535Reactome: R-HSA-9679191Reactome: R-HSA-9692916 |
| Cellular Localisation | CytoplasmCytosolSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a proteinPpiase Fkbp1a protein12 Kda Fk506-Binding Protein protein12 Kda Fkbp proteinFkbp-12 proteinCalstabin-1 proteinFk506-Binding Protein 1a proteinFkbp-1a proteinImmunophilin Fkbp12 proteinRotamase proteinFKBP1A proteinFKBP1 proteinFKBP12 protein |
Information sourced from Uniprot.org
