Human FKBP12.6/FKBP1B protein (Recombinant) (His-Tag) (STJP017390)

Name: Human FKBP12.6/FKBP1B protein (Recombinant) (His-Tag) (STJP017390)
SKU: STJP017390
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017390

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Short Description	Recombinant-Human FKBP12.6/FKBP1B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Enzyme Activity
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity	Specific activity is > 800nmol/min/mg, and is defined as the amount of enzyme cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.

Gene Symbol	FKBP1B
Gene ID	2281
Uniprot ID	FKB1B_HUMAN
Accession Number	NP_004107
Immunogen	Human
Immunogen Region	1-108aa
Immunogen Sequence	MGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE

Tissue Specificity	Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
Function	Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1b Ppiase Fkbp1b 12.6 Kda Fk506-Binding Protein 12.6 Kda Fkbp Fkbp-12.6 Fk506-Binding Protein 1b Fkbp-1b Immunophilin Fkbp12.6 Rotamase H-Fkbp-12
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-5578775
Cellular Localisation	Cytoplasm Sarcoplasmic Reticulum
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1b protein Ppiase Fkbp1b protein 12.6 Kda Fk506-Binding Protein protein 12.6 Kda Fkbp protein Fkbp-12.6 protein Fk506-Binding Protein 1b protein Fkbp-1b protein Immunophilin Fkbp12.6 protein Rotamase protein H-Fkbp-12 protein FKBP1B protein FKBP12.6 protein FKBP1L protein FKBP9 protein OTK4 protein

Information sourced from Uniprot.org