Human FIS1 protein (Recombinant) (N-His) (STJP006258)

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STJP006258
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FIS1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FIS1
Gene ID: 51024
Uniprot ID: FIS1_HUMAN
Immunogen Region: Met1-Ala117
Immunogen: Homo sapiens (Human)
Function Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis.
Protein Name Mitochondrial Fission 1 Protein
Fis1 Homolog
Hfis1
Tetratricopeptide Repeat Protein 11
Tpr Repeat Protein 11
Database Links Reactome: R-HSA-9603798
Cellular Localisation Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Peroxisome Membrane
Alternative Protein Names Mitochondrial Fission 1 Protein protein
Fis1 Homolog protein
Hfis1 protein
Tetratricopeptide Repeat Protein 11 protein
Tpr Repeat Protein 11 protein
FIS1 protein
TTC11 protein
CGI-135 protein

Information sourced from Uniprot.org

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