Human FIL1d (Interleukin 1 Delta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015309)

Human FIL1d (Interleukin 1 Delta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015309)

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STJE0015309
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.7pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description : This FIL1d Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: IL36RN
Gene ID: 26525
Uniprot ID: I36RA_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Post Translational Modifications
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name Interleukin-36 Receptor Antagonist Protein
Il-36ra
Fil1 Delta
Il-1-Related Protein 3
Il-1rp3
Interleukin-1 Hy1
Il-1hy1
Interleukin-1 Delta
Il-1 Delta
Interleukin-1 Family Member 5
Il-1f5
Interleukin-1 Receptor Antagonist Homolog 1
Il-1ra Homolog 1
Interleukin-1-Like Protein 1
Il-1l1
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-36 Receptor Antagonist Protein ELISA kit
Il-36ra ELISA kit
Fil1 Delta ELISA kit
Il-1-Related Protein 3 ELISA kit
Il-1rp3 ELISA kit
Interleukin-1 Hy1 ELISA kit
Il-1hy1 ELISA kit
Interleukin-1 Delta ELISA kit
Il-1 Delta ELISA kit
Interleukin-1 Family Member 5 ELISA kit
Il-1f5 ELISA kit
Interleukin-1 Receptor Antagonist Homolog 1 ELISA kit
Il-1ra Homolog 1 ELISA kit
Interleukin-1-Like Protein 1 ELISA kit
Il-1l1 ELISA kit
IL36RN ELISA kit
FIL1D ELISA kit
IL1F5 ELISA kit
IL1HY1 ELISA kit
IL1L1 ELISA kit
IL1RP3 ELISA kit
UNQ1896 ELISA kit
PRO4342 ELISA kit
output

Information sourced from Uniprot.org

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