| Tissue Specificity | Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. |
| Function | Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. |
| Protein Name | Fibroblast Growth Factor-Binding Protein 1Fgf-BpFgf-Bp1Fgf-Binding Protein 1Fgfbp-117 Kda Heparin-Binding Growth Factor-Binding Protein17 Kda Hbgf-Binding ProteinHbp17 |
| Database Links | Reactome: R-HSA-190377 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular And Plasma Membrane-AssociatedColocalizes With Hspg2 In The Pericellular Environment Of Squamous Cell Carcinomas |
| Alternative Protein Names | Fibroblast Growth Factor-Binding Protein 1 proteinFgf-Bp proteinFgf-Bp1 proteinFgf-Binding Protein 1 proteinFgfbp-1 protein17 Kda Heparin-Binding Growth Factor-Binding Protein protein17 Kda Hbgf-Binding Protein proteinHbp17 proteinFGFBP1 proteinFGFBP proteinHBP17 protein |
Information sourced from Uniprot.org
