Human FFAR1 protein (Recombinant) (N-His-KSI) (STJP010632)

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STJP010632
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Short Description :Recombinant-Human FFAR1-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:FFAR1
Gene ID:2864
Uniprot ID:FFAR1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:[Glu65-Cys79] & [Gly143-Ser178] & [Cys201-Ala223] & [Gly280-Lys300]
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Protein Name Free Fatty Acid Receptor 1
G-Protein Coupled Receptor 40
Database Links Reactome: R-HSA-381771
Reactome: R-HSA-400511
Reactome: R-HSA-416476
Reactome: R-HSA-434316
Reactome: R-HSA-444209
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Free Fatty Acid Receptor 1 protein
G-Protein Coupled Receptor 40 protein
FFAR1 protein
GPR40 protein

Information sourced from Uniprot.org