Human FDFT1 protein (Recombinant) (His-Tag) (STJP018885)

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STJP018885
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FDFT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: FDFT1
Gene ID: 2222
Uniprot ID: FDFT_HUMAN
Immunogen Region: 1-283aa
Accession Number: NP_004453
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMEFVKCL GHPEEFYNLV RFRIGGKRKV MPKMDQDSLS SSLKTCYKYL NQTSRSFAAV IQALDGEMRN AVCIFYLVLR ALDTLEDDMT ISVEKKVPLL HNFHSFLYQP DWRFMESKEK DRQVLEDFPT ISLEFRNLAE KYQTVIADIC RRMGIGMAEF LDKHVTSEQE WDKYCHYVAG LVGIGLSRLF SASEFEDPLV GEDTERAN
Tissue Specificity Widely expressed.
Function Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
Protein Name Squalene Synthase
Sqs
Ss
Fpp -Fpp Farnesyltransferase
Farnesyl-Diphosphate Farnesyltransferase
Farnesyl-Diphosphate Farnesyltransferase 1
Database Links Reactome: R-HSA-191273
Reactome: R-HSA-1989781
Reactome: R-HSA-2426168
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Squalene Synthase protein
Sqs protein
Ss protein
Fpp -Fpp Farnesyltransferase protein
Farnesyl-Diphosphate Farnesyltransferase protein
Farnesyl-Diphosphate Farnesyltransferase 1 protein
FDFT1 protein

Information sourced from Uniprot.org

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