Function | Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization. |
Protein Name | Fc Receptor-Like Protein 5Fcr-Like Protein 5Fcrl5Bxmas1Fc Receptor Homolog 5Fcrh5Immune Receptor Translocation-Associated Protein 2Cd Antigen Cd307e |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | Fc Receptor-Like Protein 5 proteinFcr-Like Protein 5 proteinFcrl5 proteinBxmas1 proteinFc Receptor Homolog 5 proteinFcrh5 proteinImmune Receptor Translocation-Associated Protein 2 proteinCd Antigen Cd307e proteinFCRL5 proteinFCRH5 proteinIRTA2 proteinUNQ503 proteinPRO820 protein |
Information sourced from Uniprot.org