Human FcRH5/FcRL5 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001583)

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STJP001583
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FcRH5/FcRL5-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: FCRL5
Gene ID: 83416
Uniprot ID: FCRL5_HUMAN
Immunogen Region: Gln16-Gly851
Immunogen: DNA sequence encoding Human FcRH5/FcRL5 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization.
Protein Name Fc Receptor-Like Protein 5
Fcr-Like Protein 5
Fcrl5
Bxmas1
Fc Receptor Homolog 5
Fcrh5
Immune Receptor Translocation-Associated Protein 2
Cd Antigen Cd307e
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Fc Receptor-Like Protein 5 protein
Fcr-Like Protein 5 protein
Fcrl5 protein
Bxmas1 protein
Fc Receptor Homolog 5 protein
Fcrh5 protein
Immune Receptor Translocation-Associated Protein 2 protein
Cd Antigen Cd307e protein
FCRL5 protein
FCRH5 protein
IRTA2 protein
UNQ503 protein
PRO820 protein

Information sourced from Uniprot.org