Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V) protein (Recombinant) (C-His) (STJP019933)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly17-Ser200) of Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V) (Ac
General Information
| Short Description | Recombinant-Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V)-C-His protein was developed in hek293 cells using the region Gly17-Ser200. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCGR3B |
| Gene ID | 2215 |
| Uniprot ID | FCG3B_HUMAN |
| Immunogen | Recombinant Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly17-Ser200) of Human Fc-gamma RIII beta/FCGR3B/CD16b (S36R, N82D, I106V) (Ac |
| Immunogen Region | Gly17-Ser200 |
| Immunogen Sequence | GMRTEDLPKAVVFLEPQWYS VLEKDSVTLKCQGAYSPEDN STQWFHNENLISSQASSYFI DAATVNDSGEYRCQTNLSTL SDPVQLEVHIGWLLLQAPRW VFKEEDPIHLRCHSWKNTAL HKVTYLQNGKDRKYFHHNSD FHIPKATLKDSGSYFCRGLV GSKNVSSETVNITITQGLAV STIS |
Additional Info
| Tissue Specificity | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. |
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B proteinFc-Gamma Riii-Beta proteinCd16-I proteinFc-Gamma Riii proteinFc-Gamma Riiib proteinFcriii proteinFcriiib proteinFcr-10 proteinIgg Fc Receptor Iii-1 proteinCd Antigen Cd16b proteinFCGR3B proteinCD16B proteinFCG3 proteinFCGR3 proteinIGFR3 protein |
Information sourced from Uniprot.org