| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FCGR2B at 2 Mu g/mL (100 Mu L/well) can bind biotinylated Human IgG1 with a linear range of 0.0048-2.81 Mu g/mL.|2.Measured by its binding ability in a functional |
| Gene Symbol: | FCGR2B |
| Gene ID: | 2213 |
| Uniprot ID: | FCG2B_HUMAN |
| Immunogen: | Recombinant Human Fc-gamma RIIb/CD32b Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala46-Pro217) of human Fc gamma RIIB/C (Accession #NP_003992.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | APPKAVLKLEPQWINVLQED SVTLTCRGTHSPESDSIQWF HNGNLIPTHTQPSYRFKANN NDSGEYTCQTGQTSLSDPVH LTVLSEWLVLQTPHLEFQEG ETIVLRCHSWKDKPLVKVTF FQNGKSKKFSRSDPNFSIPQ ANHSHSGDYHCTGNIGYTLY SSKPVTITVQAP |
| Tissue Specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B Igg Fc Receptor Ii-B Cdw32 Fc-Gamma Rii-B Fc-Gamma-Riib Fcrii-B Cd Antigen Cd32 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B protein Igg Fc Receptor Ii-B protein Cdw32 protein Fc-Gamma Rii-B protein Fc-Gamma-Riib protein Fcrii-B protein Cd Antigen Cd32 protein FCGR2B protein CD32 protein FCG2 protein IGFR2 protein |
Information sourced from Uniprot.org