| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | FCGR1A |
| Gene ID: | 2209 |
| Uniprot ID: | FCGR1_HUMAN |
| Immunogen Region: | Gln16-Pro288 |
| Immunogen: | Biotinylated Recombinant Human Fc gamma RI/FCGR1/CD64 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln16-Pro288) of Human Fc gamma RI/CD64 (Accession #P12314-1) fused with a C-His&Avi tag at th |
| Immunogen Sequence: | QVDTTKAVITLQPPWVSVFQ EETVTLHCEVLHLPGSSSTQ WFLNGTATQTSTPSYRITSA SVNDSGEYRCQRGLSGRSDP IQLEIHRGWLLLQVSSRVFT EGEPLALRCHAWKDKLVYNV LYYRNGKAFKFFHWNSNLTI LKTNISHNGTYHCSGMGKHR YTSAGISVTVKELFPAPVLN ASVTSPLLEGNLVTLSCETK LLLQRPGLQLYFSFYMGSKT LRGRNTSSEYQILTARRED |
| Tissue Specificity | Monocyte/macrophage specific. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. |
| Protein Name | High Affinity Immunoglobulin Gamma Fc Receptor IIgg Fc Receptor IFc-Gamma RiFcriFc-Gamma RiaFcgammariaCd Antigen Cd64 |
| Database Links | Reactome: R-HSA-1236978Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-877300Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinStabilized At The Cell Membrane Through Interaction With Fcer1g |
| Alternative Protein Names | High Affinity Immunoglobulin Gamma Fc Receptor I proteinIgg Fc Receptor I proteinFc-Gamma Ri proteinFcri proteinFc-Gamma Ria proteinFcgammaria proteinCd Antigen Cd64 proteinFCGR1A proteinFCG1 proteinFCGR1 proteinIGFR1 protein |
Information sourced from Uniprot.org
