Human FBLIM1 protein (Recombinant) (His-Tag) (STJP018220)

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STJP018220
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FBLIM1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: FBLIM1
Gene ID: 54751
Uniprot ID: FBLI1_HUMAN
Immunogen Region: 1-373aa
Accession Number: NP_060026
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMASKPEK RVASSVFITL APPRRDVAVA EEVRQAVCEA RRGRPWEAPA PMKTPEAGLA GRPSPWTTPG RAAATVPAAP MQLFNGGCPP PPPVLDGEDV LPDLDLLPPP PPPPPVLLPS EEEAPAPMGA SLIADLEQLH LSPPPPPPQA PAEGPSVQPG PLRPMEEELP PPPAEPVEKG ASTDICAFCH KTVSPRELAV EAMKRQYH
Tissue Specificity Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
Protein Name Filamin-Binding Lim Protein 1
Fblp-1
Migfilin
Mitogen-Inducible 2-Interacting Protein
Mig2-Interacting Protein
Database Links Reactome: R-HSA-446353
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Stress Fiber
Associated With Actin Stress Fiber At Cell-Ecm Focal Adhesion Sites
Isoform 1 And Isoform 3 Are Recruited And Localized At Actin Stress Fibers And Clustered At Cell-Emc Adhesion Sites Through Interaction With Fermt2
Isoform 2 Is Localized At Actin Stress Fibers
Alternative Protein Names Filamin-Binding Lim Protein 1 protein
Fblp-1 protein
Migfilin protein
Mitogen-Inducible 2-Interacting Protein protein
Mig2-Interacting Protein protein
FBLIM1 protein
FBLP1 protein

Information sourced from Uniprot.org

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