| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. N-glycosylated. Glycosylation enhances apoptotic activity. Phosphorylated by FGR on tyrosine residues.this is required for ubiquitination and subsequent internalization. Monoubiquitinated. |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 6Apoptosis Antigen LigandAptlCd95 LigandCd95-LFas Antigen LigandFas LigandFaslCd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble FormReceptor-Binding Fasl EctodomainSoluble Fas LigandSfasl - Adam10-Processed Fasl FormApl - Fasl Intracellular DomainFasl IcdSppl2a-Processed Fasl FormSpa |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6785807Reactome: R-HSA-69416Reactome: R-HSA-75157Reactome: R-HSA-8862803Reactome: R-HSA-9614657 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle LumenLysosome LumenIs Internalized Into Multivesicular Bodies Of Secretory Lysosomes After Phosphorylation By Fgr And MonoubiquitinationColocalizes With The Sppl2a Protease At The Cell MembraneTumor Necrosis Factor Ligand Superfamily Member 6Soluble Form: SecretedMay Be Released Into The Extracellular Fluid By Cleavage From The Cell SurfaceFasl Intracellular Domain: NucleusThe Fasl Icd Cytoplasmic Form Is Translocated Into The Nucleus |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 6 proteinApoptosis Antigen Ligand proteinAptl proteinCd95 Ligand proteinCd95-L proteinFas Antigen Ligand proteinFas Ligand proteinFasl proteinCd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form proteinReceptor-Binding Fasl Ectodomain proteinSoluble Fas Ligand proteinSfasl - Adam10-Processed Fasl Form proteinApl - Fasl Intracellular Domain proteinFasl Icd proteinSppl2a-Processed Fasl Form proteinSpa proteinFASLG proteinAPT1LG1 proteinCD95L proteinFASL proteinTNFSF6 protein |
Information sourced from Uniprot.org
