Human EZR protein (Recombinant) (N-His) (STJP004133)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EZR-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | EZR |
| Gene ID | 7430 |
| Uniprot ID | EZRI_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg295 |
Additional Info
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. |
| Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. |
| Protein Name | EzrinCytovillinVillin-2P81 |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-437239Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionMicrovillus MembraneRuffle MembraneCytoplasmCell CortexCytoskeletonMicrovillusLocalization To The Apical Membrane Of Parietal Cells Depends On The Interaction With Pals1Localizes To Cell Extensions And Peripheral Processes Of AstrocytesMicrovillar Peripheral Membrane Protein (Cytoplasmic Side) |
| Alternative Protein Names | Ezrin proteinCytovillin proteinVillin-2 proteinP81 proteinEZR proteinVIL2 protein |
Information sourced from Uniprot.org