| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. |
| Protein Name | Epithelial Splicing Regulatory Protein 1Rna-Binding Motif Protein 35aRna-Binding Protein 35a |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-6803529 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Epithelial Splicing Regulatory Protein 1 proteinRna-Binding Motif Protein 35a proteinRna-Binding Protein 35a proteinESRP1 proteinRBM35A protein |
Information sourced from Uniprot.org
