Human ESRP1 protein (Recombinant) (N-His) (STJP008990)

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STJP008990
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ESRP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ESRP1
Gene ID: 54845
Uniprot ID: ESRP1_HUMAN
Immunogen Region: Met1-Ser193
Immunogen: Homo sapiens (Human)
Function mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium.
Protein Name Epithelial Splicing Regulatory Protein 1
Rna-Binding Motif Protein 35a
Rna-Binding Protein 35a
Database Links Reactome: R-HSA-6802952
Reactome: R-HSA-6803529
Cellular Localisation Nucleus
Alternative Protein Names Epithelial Splicing Regulatory Protein 1 protein
Rna-Binding Motif Protein 35a protein
Rna-Binding Protein 35a protein
ESRP1 protein
RBM35A protein

Information sourced from Uniprot.org

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