Human ERO1L alpha protein (Recombinant) (His-Tag) (STJP018765)

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STJP018765
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ERO1L alpha-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERO1A
Gene ID: 30001
Uniprot ID: ERO1A_HUMAN
Immunogen Region: 24-468aa
Accession Number: NP_055399
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTS
Tissue Specificity Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.
Post Translational Modifications N-glycosylated. The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131. Phosphorylated on Ser-145 by FAM20C in the Golgi which increases its enzymatic activity. Phosphorylation is induced by lactation. It is also induced by hypoxia and reductive stress.
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.
Protein Name Ero1-Like Protein Alpha
Ero1-L
Ero1-L-Alpha
Endoplasmic Oxidoreductin-1-Like Protein
Endoplasmic Reticulum Oxidoreductase Alpha
Oxidoreductin-1-L-Alpha
Database Links Reactome: R-HSA-3299685
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Lumenal Side
Golgi Apparatus Lumen
Secreted
Cell Projection
Dendrite
The Association With Erp44 Is Essential For Its Retention In The Endoplasmic Reticulum
In Neurons
It Localizes To Dendrites
Alternative Protein Names Ero1-Like Protein Alpha protein
Ero1-L protein
Ero1-L-Alpha protein
Endoplasmic Oxidoreductin-1-Like Protein protein
Endoplasmic Reticulum Oxidoreductase Alpha protein
Oxidoreductin-1-L-Alpha protein
ERO1A protein
ERO1L protein
UNQ434 protein
PRO865 protein

Information sourced from Uniprot.org

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