Human ERLIN1 protein (Recombinant) (N-His) (STJP008333)

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STJP008333
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ERLIN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ERLIN1
Gene ID: 10613
Uniprot ID: ERLN1_HUMAN
Immunogen Region: Glu29-Thr173
Immunogen: Homo sapiens (Human)
Post Translational Modifications Deubiquitinated by USP25.leading to stabilization.
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.
Protein Name Erlin-1
Endoplasmic Reticulum Lipid Raft-Associated Protein 1
Protein Ke04
Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1
Spfh Domain-Containing Protein 1
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5678895
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane
Alternative Protein Names Erlin-1 protein
Endoplasmic Reticulum Lipid Raft-Associated Protein 1 protein
Protein Ke04 protein
Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 protein
Spfh Domain-Containing Protein 1 protein
ERLIN1 protein
C10orf69 protein
KE04 protein
KEO4 protein
SPFH1 protein

Information sourced from Uniprot.org

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