Human ERCC1 protein (Recombinant) (N-His) (STJP003814)

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STJP003814
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Short Description :Recombinant-Human ERCC1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:ERCC1
Gene ID:2067
Uniprot ID:ERCC1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Pro297
Function Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Isoform 2: Not functional in the nucleotide excision repair pathway. Isoform 3: Not functional in the nucleotide excision repair pathway. Isoform 4: Not functional in the nucleotide excision repair pathway.
Protein Name Dna Excision Repair Protein Ercc-1
Database Links Reactome: R-HSA-5685938
Reactome: R-HSA-5696395
Reactome: R-HSA-5696400
Reactome: R-HSA-6782135
Reactome: R-HSA-6783310
Cellular Localisation Isoform 1: Nucleus
Isoform 2: Cytoplasm
Nucleus
Isoform 3: Nucleus
Isoform 4: Nucleus
Alternative Protein Names Dna Excision Repair Protein Ercc-1 protein
ERCC1 protein

Information sourced from Uniprot.org