| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ERBIN-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ERBIN |
| Gene ID: | 55914 |
| Uniprot ID: | ERBIN_HUMAN |
| Immunogen Region: | Lys1319-Val1407 |
| Immunogen: | Homo sapiens (Human) |
| Function | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion. |
| Protein Name | ErbinDensin-180-Like ProteinErbb2-Interacting ProteinProtein Lap2 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-8863795Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9634285Reactome: R-HSA-9652282Reactome: R-HSA-9664565Reactome: R-HSA-9665233Reactome: R-HSA-9665244Reactome: R-HSA-9665245Reactome: R-HSA-9665246Reactome: R-HSA-9665247Reactome: R-HSA-9665249Reactome: R-HSA-9665250Reactome: R-HSA-9665251Reactome: R-HSA-9665348Reactome: R-HSA-9665686Reactome: R-HSA-9665737 |
| Cellular Localisation | Cell JunctionHemidesmosomeNucleus MembraneBasolateral Cell MembraneFound In HemidesmosomesWhich Are Cell-Substrate Adhesion Complexes In Stratified EpitheliaIn Transfected CellsEither Diffusely Distributed Over The Cytoplasm Or Concentrated At The Basolateral MembraneColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Protein Names | Erbin proteinDensin-180-Like Protein proteinErbb2-Interacting Protein proteinProtein Lap2 proteinERBIN proteinERBB2IP proteinKIAA1225 proteinLAP2 protein |
Information sourced from Uniprot.org