Tissue Specificity | Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE). |
Post Translational Modifications | |
Function | Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation. Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages. |
Protein Name | Epithelial-Stromal Interaction Protein 1 |
Database Links | Reactome: R-HSA-9696273 |
Cellular Localisation | |
Alternative ELISA Names | Epithelial-Stromal Interaction Protein 1 ELISA kitEPSTI1 ELISA kit |
output | |
Information sourced from Uniprot.org