| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Ephrin-B2/EFNB2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human EFNB2 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EPHB4 with a linear range of 6-400 pg/mL. |
| Gene Symbol: |
EFNB2 |
| Gene ID: |
1948 |
| Uniprot ID: |
EFNB2_HUMAN |
| Immunogen Region: |
Ile28-Ala229 |
| Immunogen: |
Recombinant Human Ephrin-B2/EFNB2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ile28-Ala229) of human Ephrin-B2/EFNB2 (Accession #NP_004084.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. |
| Protein Name | Ephrin-B2Eph-Related Receptor Tyrosine Kinase Ligand 5Lerk-5Htk LigandHtk-L |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens Junction |
| Alternative Protein Names | Ephrin-B2 proteinEph-Related Receptor Tyrosine Kinase Ligand 5 proteinLerk-5 proteinHtk Ligand proteinHtk-L proteinEFNB2 proteinEPLG5 proteinHTKL proteinLERK5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
