• Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His) (STJP000849)

Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His) (STJP000849)

SKU:
STJP000849

£63.50 - £189.50
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ep-CAM/TROP-1/CD326-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. When cells are added to EpCAM-His coated plates (1.25 Mu g/mL, 100 Mu L/well) , approximately >30% will adhere specifically after
Gene Symbol: EPCAM
Gene ID: 4072
Uniprot ID: EPCAM_HUMAN
Immunogen: Recombinant Human Ep-CAM/TROP-1/CD326 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Lys265) of human EpCAM/TROP-1 (Accession #NP_002345.2) fused with a 6×His tag at the C-terminus.
Tissue Specificity Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Post Translational Modifications Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Protein Name Epithelial Cell Adhesion Molecule
Ep-Cam
Adenocarcinoma-Associated Antigen
Cell Surface Glycoprotein Trop-1
Epithelial Cell Surface Antigen
Epithelial Glycoprotein
Egp
Epithelial Glycoprotein 314
Egp314
Hegp314
Ks 1/4 Antigen
Ksa
Major Gastrointestinal Tumor-Associated Protein Ga733-2
Tumor-Associated Calcium Signal Transducer 1
Cd Antigen Cd326
Database Links Reactome: R-HSA-202733
Cellular Localisation Lateral Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Colocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction
Alternative Protein Names Epithelial Cell Adhesion Molecule protein
Ep-Cam protein
Adenocarcinoma-Associated Antigen protein
Cell Surface Glycoprotein Trop-1 protein
Epithelial Cell Surface Antigen protein
Epithelial Glycoprotein
Egp protein
Epithelial Glycoprotein 314 protein
Egp314 protein
Hegp314 protein
Ks 1/4 Antigen protein
Ksa protein
Major Gastrointestinal Tumor-Associated Protein Ga733-2 protein
Tumor-Associated Calcium Signal Transducer 1 protein
Cd Antigen Cd326 protein
EPCAM protein
GA733-2 protein
M1S2 protein
M4S1 protein
MIC18 protein
TACSTD1 protein
TROP1 protein

Information sourced from Uniprot.org

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