Human ENPP2 protein (Recombinant-Active) (N-His) (STJP012105)

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STJP012105-100
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Short Description :Recombinant-Active-Human ENPP2-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity:Measured by its ability to cleave Bis (pNitrophenyl) Phosphate (BPNPP). The specific activity is >8, 000 pmol/min/Mu g, as measured under the described conditions.
Gene Symbol:ENPP2
Gene ID:5168
Uniprot ID:ENPP2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Asp49-Ile863
Post Translational Modifications N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. The interdomain disulfide bond between Cys-414 and Cys-806 is essential for catalytic activity.
Function Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Its major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name Autotaxin
Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2
E-Npp 2
Extracellular Lysophospholipase D
Lysopld
Database Links Reactome: R-HSA-199220
Cellular Localisation Secreted
Alternative Protein Names Autotaxin protein
Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 protein
E-Npp 2 protein
Extracellular Lysophospholipase D protein
Lysopld protein
ENPP2 protein
ATX protein
PDNP2 protein

Information sourced from Uniprot.org

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