| Tissue Specificity | Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils. |
| Post Translational Modifications | N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. |
| Function | Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro. |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3E-Npp 3Npp3Alkaline Phosphodiesterase IDinucleoside PolyphosphataseNucleotide DiphosphataseNucleotide PyrophosphataseNppasePhosphodiesterase I BetaPd-IbetaPhosphodiesterase I/Nucleotide Pyrophosphatase 3Cd Antigen Cd203c |
| Database Links | Reactome: R-HSA-199220 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSecretedDetected At The Cell Surface Of BasophilsDetected At The Apical Plasma Membrane Of Bile Duct CellsLocated To The Apical Surface In Intestinal And Kidney Epithelial CellsSecreted In SerumAnd In Lumen Of Epithelial Cells |
| Alternative Protein Names | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 proteinE-Npp 3 proteinNpp3 proteinAlkaline Phosphodiesterase I proteinDinucleoside Polyphosphatase proteinNucleotide Diphosphatase proteinNucleotide Pyrophosphatase proteinNppase proteinPhosphodiesterase I Beta proteinPd-Ibeta proteinPhosphodiesterase I/Nucleotide Pyrophosphatase 3 proteinCd Antigen Cd203c proteinENPP3 proteinPDNP3 protein |
Information sourced from Uniprot.org
