Human Endophilin A1/SH3GL2 protein (Recombinant) (His-Tag) (STJP017622)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Endophilin A1/SH3GL2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SH3GL2 |
| Gene ID | 6456 |
| Uniprot ID | SH3G2_HUMAN |
| Accession Number | NP_003017 |
| Immunogen | Human |
| Immunogen Region | 1-352aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum. |
| Function | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. |
| Protein Name | Endophilin-A1Een-B1Endophilin-1Sh3 Domain Protein 2aSh3 Domain-Containing Grb2-Like Protein 2 |
| Database Links | Reactome: R-HSA-177504Reactome: R-HSA-182971Reactome: R-HSA-2132295Reactome: R-HSA-432720Reactome: R-HSA-432722Reactome: R-HSA-437239Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinEarly EndosomePresynapse |
| Alternative Protein Names | Endophilin-A1 proteinEen-B1 proteinEndophilin-1 proteinSh3 Domain Protein 2a proteinSh3 Domain-Containing Grb2-Like Protein 2 proteinSH3GL2 proteinCNSA2 proteinSH3D2A protein |
Information sourced from Uniprot.org