| Tissue Specificity | Detected at macrophage membranes (at protein level). Ubiquitous. |
| Post Translational Modifications | Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro). |
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages.this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (Probable). |
| Protein Name | E3 Ubiquitin-Protein Transferase MaeaCell Proliferation-Inducing Gene 5 ProteinErythroblast Macrophage ProteinHuman Lung Cancer Oncogene 10 ProteinHlc-10Macrophage Erythroblast AttacherP44emlp |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus MatrixCell MembraneCytoskeletonDetected In A NuclearSpeckled-Like PatternLocalized With Condensed Chromatin At ProphaseDetected In Nuclear Spindle Poles At Metaphase And In The Contractile Ring During Telophase And CytokinesisPresent In CytoplasmNuclear Matrix And At The Cell Surface In MacrophagesPredominantly Nuclear In Immature Macrophages And Predominantly Detected At The Cell Surface In Mature MacrophagesColocalizes With F-Actin In Macrophages |
| Alternative Protein Names | E3 Ubiquitin-Protein Transferase Maea proteinCell Proliferation-Inducing Gene 5 Protein proteinErythroblast Macrophage Protein proteinHuman Lung Cancer Oncogene 10 Protein proteinHlc-10 proteinMacrophage Erythroblast Attacher proteinP44emlp proteinMAEA proteinEMP proteinHLC10 proteinPIG5 protein |
Information sourced from Uniprot.org
