Human EMC10 protein (Recombinant) (N-His) (STJP015841)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human EMC10-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | EMC10 |
| Gene ID | 284361 |
| Uniprot ID | EMC10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly50-Pro190 |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways. |
| Protein Name | Er Membrane Protein Complex Subunit 10Hematopoietic Signal Peptide-Containing Membrane Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Er Membrane Protein Complex Subunit 10 proteinHematopoietic Signal Peptide-Containing Membrane Domain-Containing Protein 1 proteinEMC10 proteinC19orf63 proteinINM02 proteinUNQ764 proteinPRO1556 protein |
Information sourced from Uniprot.org