Human ELP3 protein (Recombinant) (N-His) (STJP008502)

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STJP008502
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ELP3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ELP3
Gene ID: 55140
Uniprot ID: ELP3_HUMAN
Immunogen Region: Lys79-Lys547
Immunogen: Homo sapiens (Human)
Post Translational Modifications Tyrosine-phosphorylated.phosphorylation on Tyr-202 does not affect elongator complex integrity or ELP3 protein stability. Also serine/threonine-phosphorylated.
Function Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins.such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex.
Protein Name Elongator Complex Protein 3
Help3
Trna Uridine(34 Acetyltransferase
Database Links Reactome: R-HSA-3214847
Cellular Localisation Cytoplasm
Nucleus
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Alternative Protein Names Elongator Complex Protein 3 protein
Help3 protein
Trna Uridine(34 Acetyltransferase protein
ELP3 protein

Information sourced from Uniprot.org

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