| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ELANE-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ELANE |
| Gene ID: | 1991 |
| Uniprot ID: | ELNE_HUMAN |
| Immunogen Region: | Ile30-Gln247 |
| Immunogen: | Homo sapiens (Human) |
| Function | Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. |
| Protein Name | Neutrophil ElastaseBone Marrow Serine ProteaseElastase-2Human Leukocyte ElastaseHleMedullasinPmn Elastase |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-5620971Reactome: R-HSA-6798695Reactome: R-HSA-6803157Reactome: R-HSA-977606 |
| Cellular Localisation | Cytoplasmic VesiclePhagosomeLocalized In Phagolysosomes Following Ingestion Of EColi By Neutrophils |
| Alternative Protein Names | Neutrophil Elastase proteinBone Marrow Serine Protease proteinElastase-2 proteinHuman Leukocyte Elastase proteinHle proteinMedullasin proteinPmn Elastase proteinELANE proteinELA2 protein |
Information sourced from Uniprot.org