Human EIF4EBP2/4E-BP2 protein (Recombinant) (N-His) (STJP014624)

Name: Human EIF4EBP2/4E-BP2 protein (Recombinant) (N-His) (STJP014624)
SKU: STJP014624-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP014624-100

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Short Description	Recombinant-Human EIF4EBP2/4E-BP2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Applications	ELISA/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Protein Name	Eukaryotic Translation Initiation Factor 4e-Binding Protein 2 4e-Bp2 Eif4e-Binding Protein 2
Database Links
Cellular Localisation	Cytoplasm Nucleus
Alternative Protein Names	Eukaryotic Translation Initiation Factor 4e-Binding Protein 2 protein 4e-Bp2 protein Eif4e-Binding Protein 2 protein EIF4EBP2 protein

Information sourced from Uniprot.org