Human EIF4EBP2/4E-BP2 protein (Recombinant) (N-His) (STJP014624)

SKU:
STJP014624-100
£503.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EIF4EBP2/4E-BP2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: EIF4EBP2
Gene ID: 1979
Uniprot ID: 4EBP2_HUMAN
Immunogen Region: Met1-Ile120
Immunogen: Homo sapiens (Human)
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Protein Name Eukaryotic Translation Initiation Factor 4e-Binding Protein 2
4e-Bp2
Eif4e-Binding Protein 2
Database Links
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Eukaryotic Translation Initiation Factor 4e-Binding Protein 2 protein
4e-Bp2 protein
Eif4e-Binding Protein 2 protein
EIF4EBP2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E.coli SDS-PAGE/WB/ELISA/Immunogen
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP003417 Human TNFSF15 protein (Recombinant) (N-His) (STJP003417) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP003801 Human CTSL protein (Recombinant) (N-His) (STJP003801) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP005165 Human GSTM4 protein (Recombinant) (N-His) (STJP005165) E.coli ELISA/Immunogen/SDS-PAGE/WB

Related Products

!