| Function | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit GEif3gEukaryotic Translation Initiation Factor 3 Rna-Binding SubunitEif-3 Rna-Binding SubunitEukaryotic Translation Initiation Factor 3 Subunit 4Eif-3-DeltaEif3 P42Eif3 P44 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | CytoplasmNucleusPerinuclear RegionColocalizes With Aifm1 In The Nucleus And Perinuclear Region |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 3 Subunit G proteinEif3g proteinEukaryotic Translation Initiation Factor 3 Rna-Binding Subunit proteinEif-3 Rna-Binding Subunit proteinEukaryotic Translation Initiation Factor 3 Subunit 4 proteinEif-3-Delta proteinEif3 P42 proteinEif3 P44 proteinEIF3G proteinEIF3S4 protein |
Information sourced from Uniprot.org
