Human EIF3G protein (Recombinant) (N-GST & C-His) (STJP010750)

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STJP010750
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EIF3G-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: EIF3G
Gene ID: 8666
Uniprot ID: EIF3G_HUMAN
Immunogen Region: Gln230-Asn320
Immunogen: Homo sapiens (Human)
Function RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit G
Eif3g
Eukaryotic Translation Initiation Factor 3 Rna-Binding Subunit
Eif-3 Rna-Binding Subunit
Eukaryotic Translation Initiation Factor 3 Subunit 4
Eif-3-Delta
Eif3 P42
Eif3 P44
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Nucleus
Perinuclear Region
Colocalizes With Aifm1 In The Nucleus And Perinuclear Region
Alternative Protein Names Eukaryotic Translation Initiation Factor 3 Subunit G protein
Eif3g protein
Eukaryotic Translation Initiation Factor 3 Rna-Binding Subunit protein
Eif-3 Rna-Binding Subunit protein
Eukaryotic Translation Initiation Factor 3 Subunit 4 protein
Eif-3-Delta protein
Eif3 P42 protein
Eif3 P44 protein
EIF3G protein
EIF3S4 protein

Information sourced from Uniprot.org