SDS-PAGE gel of recombinant human eIF-3 beta EIF3I protein under reducing conditions

Human eIF-3 beta/EIF3I protein (Recombinant) (His-Tag) (STJP018494)

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STJP018494
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Short Description :Recombinant-Human eIF-3 beta/EIF3I-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:EIF3I
Gene ID:8668
Uniprot ID:EIF3I_HUMAN
Accession Number:NP_003748
Immunogen:Human
Immunogen Region:1-325aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMKPILLQ GHERSITQIK YNREGDLLFT VAKDPIVNVW YSVNGERLGT YMGHTGAVWC VDADWDTKHV LTGSADNSCR LWDCETGKQL ALLKTNSAVR TCGFDFGGNI IMFSTDKQMG YQCFVSFFDL RDPSQIDNNE PYMKIPCNDS KITSAVWGPL GECIIAGHES GELNQYSAKS GEVLVNVKEH SRQINDIQLS RDMTMFVT
Post Translational Modifications Phosphorylated by TGF-beta type II receptor.
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit I
Eif3i
Eukaryotic Translation Initiation Factor 3 Subunit 2
Tgf-Beta Receptor-Interacting Protein 1
Trip-1
Eif-3-Beta
Eif3 P36
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Alternative Protein Names Eukaryotic Translation Initiation Factor 3 Subunit I protein
Eif3i protein
Eukaryotic Translation Initiation Factor 3 Subunit 2 protein
Tgf-Beta Receptor-Interacting Protein 1 protein
Trip-1 protein
Eif-3-Beta protein
Eif3 P36 protein
EIF3I protein
EIF3S2 protein
TRIP1 protein

Information sourced from Uniprot.org

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