Human EHMT2 protein (Recombinant) (N-His) (STJP007897)

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STJP007897
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EHMT2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: EHMT2
Gene ID: 10919
Uniprot ID: EHMT2_HUMAN
Immunogen Region: Gly626-Thr918
Immunogen: Homo sapiens (Human)
Post Translational Modifications Methylated at Lys-185.automethylated.
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Protein Name Histone-Lysine N-Methyltransferase Ehmt2
Euchromatic Histone-Lysine N-Methyltransferase 2
Hla-B-Associated Transcript 8
Histone H3-K9 Methyltransferase 3
H3-K9-Hmtase 3
Lysine N-Methyltransferase 1c
Protein G9a
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-3214841
Reactome: R-HSA-427389
Reactome: R-HSA-6804760
Reactome: R-HSA-73762
Reactome: R-HSA-8853884
Reactome: R-HSA-8953750
Reactome: R-HSA-9843970
Cellular Localisation Nucleus
Chromosome
Associates With Euchromatic Regions
Does Not Associate With Heterochromatin
Alternative Protein Names Histone-Lysine N-Methyltransferase Ehmt2 protein
Euchromatic Histone-Lysine N-Methyltransferase 2 protein
Hla-B-Associated Transcript 8 protein
Histone H3-K9 Methyltransferase 3 protein
H3-K9-Hmtase 3 protein
Lysine N-Methyltransferase 1c protein
Protein G9a protein
EHMT2 protein
BAT8 protein
C6orf30 protein
G9A protein
KMT1C protein
NG36 protein

Information sourced from Uniprot.org

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