Human EDN1/Endothelin-1 protein (Recombinant) (N-His) (STJP003725)

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STJP003725
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EDN1/Endothelin-1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: EDN1
Gene ID: 1906
Uniprot ID: EDN1_HUMAN
Immunogen Region: Ala18-Trp212
Immunogen: Homo sapiens (Human)
Function Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.
Protein Name Endothelin-1
Preproendothelin-1
Ppet1 Cleaved Into - Endothelin-1
Et-1 - Big Endothelin-1
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-9856649
Cellular Localisation Secreted
Alternative Protein Names Endothelin-1 protein
Preproendothelin-1 protein
Ppet1 Cleaved Into - Endothelin-1 protein
Et-1 - Big Endothelin-1 protein
EDN1 protein

Information sourced from Uniprot.org

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