Human ECD protein (Recombinant) (N-His) (STJP010803)

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STJP010803
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ECD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ECD
Gene ID: 11319
Uniprot ID: ECD_HUMAN
Immunogen Region: Met10-Asn406
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated predominantly by CK2 on two serine-containing clusters.involved in cell cycle regulation activity.
Function Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
Protein Name Protein Ecdysoneless Homolog
Human Suppressor Of Gcr Two
Hsgt1
Cellular Localisation Cytoplasm
Nucleus
Predominantly Is Located In The Cytoplasm
Alternative Protein Names Protein Ecdysoneless Homolog protein
Human Suppressor Of Gcr Two protein
Hsgt1 protein
ECD protein

Information sourced from Uniprot.org

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