Human DUT protein (Recombinant) (N-His) (STJP008945)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DUT-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DUT |
| Gene ID | 1854 |
| Uniprot ID | DUT_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met112-Asn252 |
Additional Info
| Post Translational Modifications | Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated. |
| Function | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development. |
| Protein Name | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase - MitochondrialDutpaseDutp Pyrophosphatase |
| Database Links | Reactome: R-HSA-499943 P33316-2 |
| Cellular Localisation | Isoform 2: NucleusIsoform 3: Mitochondrion |
| Alternative Protein Names | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase - Mitochondrial proteinDutpase proteinDutp Pyrophosphatase proteinDUT protein |
Information sourced from Uniprot.org