Human DUSP1 protein (Recombinant) (C-His) (STJP014465)

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STJP014465-100
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Short Description :Recombinant-Human DUSP1-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for this information.
Gene Symbol:DUSP1
Gene ID:1843
Uniprot ID:DUS1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gly173-Ala314
Post Translational Modifications Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation.
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Protein Name Dual Specificity Protein Phosphatase 1
Dual Specificity Protein Phosphatase Hvh1
Mitogen-Activated Protein Kinase Phosphatase 1
Map Kinase Phosphatase 1
Mkp-1
Protein-Tyrosine Phosphatase Cl100
Database Links Reactome: R-HSA-112409
Reactome: R-HSA-5675221
Cellular Localisation Nucleus
Alternative Protein Names Dual Specificity Protein Phosphatase 1 protein
Dual Specificity Protein Phosphatase Hvh1 protein
Mitogen-Activated Protein Kinase Phosphatase 1 protein
Map Kinase Phosphatase 1 protein
Mkp-1 protein
Protein-Tyrosine Phosphatase Cl100 protein
DUSP1 protein
CL100 protein
MKP1 protein
PTPN10 protein
VH1 protein

Information sourced from Uniprot.org