Human DTNB protein (Recombinant) (N-His) (STJP003330)

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STJP003330
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DTNB-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DTNB
Gene ID: 1838
Uniprot ID: DTNB_HUMAN
Immunogen Region: Met1-Glu249
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.
Function Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.
Protein Name Dystrobrevin Beta
Dtn-B
Beta-Dystrobrevin
Cellular Localisation Cytoplasm
Postsynaptic Density
Cell Projection
Dendrite
Basal Cell Membrane
Postsynapse
Nucleus
Localized At Inhibitory Synapses On The Dendrites Of Cerebellar Purkinje Cells
Alternative Protein Names Dystrobrevin Beta protein
Dtn-B protein
Beta-Dystrobrevin protein
DTNB protein

Information sourced from Uniprot.org