Human DR1 protein (Recombinant) (His-Tag) (STJP016809)

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STJP016809
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DR1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 0.1mM PMSF, 10% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: DR1
Gene ID: 1810
Uniprot ID: NC2B_HUMAN
Immunogen Region: 1-176aa
Accession Number: NP_001929.1
Immunogen: Human
Immunogen Sequence: MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI
Post Translational Modifications Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Protein Name Protein Dr1
Down-Regulator Of Transcription 1
Negative Cofactor 2-Beta
Nc2-Beta
Tata-Binding Protein-Associated Phosphoprotein
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Alternative Protein Names Protein Dr1 protein
Down-Regulator Of Transcription 1 protein
Negative Cofactor 2-Beta protein
Nc2-Beta protein
Tata-Binding Protein-Associated Phosphoprotein
DR1 protein

Information sourced from Uniprot.org

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