Human DPP8 protein (Recombinant) (N-His) (STJP006354)

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STJP006354
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DPP8-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DPP8
Gene ID: 54878
Uniprot ID: DPP8_HUMAN
Immunogen Region: Met8-Gln199
Immunogen: Homo sapiens (Human)
Function Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition.
Protein Name Dipeptidyl Peptidase 8
Dp8
Dipeptidyl Peptidase Iv-Related Protein 1
Dprp-1
Dipeptidyl Peptidase Viii
Dpp Viii
Prolyl Dipeptidase Dpp8
Cellular Localisation Cytoplasm
Alternative Protein Names Dipeptidyl Peptidase 8 protein
Dp8 protein
Dipeptidyl Peptidase Iv-Related Protein 1 protein
Dprp-1 protein
Dipeptidyl Peptidase Viii protein
Dpp Viii protein
Prolyl Dipeptidase Dpp8 protein
DPP8 protein
DPRP1 protein
MSTP097 protein
MSTP135 protein
MSTP141 protein

Information sourced from Uniprot.org