| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DOCK2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | DOCK2 |
| Gene ID: | 1794 |
| Uniprot ID: | DOCK2_HUMAN |
| Immunogen Region: | Ile390-Glu635 |
| Immunogen: | Homo sapiens (Human) |
| Function | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. |
| Protein Name | Dedicator Of Cytokinesis Protein 2 |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-983231 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinCytoplasmCytoskeletonColocalizes With F-Actin |
| Alternative Protein Names | Dedicator Of Cytokinesis Protein 2 proteinDOCK2 proteinKIAA0209 protein |
Information sourced from Uniprot.org