Human DNAJB2 protein (Recombinant) (N-GST & C-His) (STJP008826)

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STJP008826
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DNAJB2-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DNAJB2
Gene ID: 3300
Uniprot ID: DNJB2_HUMAN
Immunogen Region: Ala2-Gly91
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by STUB1.does not lead to proteasomal degradation.
Function Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.
Protein Name Dnaj Homolog Subfamily B Member 2
Heat Shock 40 Kda Protein 3
Heat Shock Protein J1
Hsj-1
Cellular Localisation Isoform 2: Cytoplasm
Nucleus
Isoform 1: Endoplasmic Reticulum Membrane
Lipid-Anchor
Cytoplasmic Side
Alternative Protein Names Dnaj Homolog Subfamily B Member 2 protein
Heat Shock 40 Kda Protein 3 protein
Heat Shock Protein J1 protein
Hsj-1 protein
DNAJB2 protein
HSJ1 protein
HSPF3 protein

Information sourced from Uniprot.org

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