Human DMPK protein (Recombinant) (N-His) (STJP016188)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DMPK-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | DMPK |
| Gene ID | 1760 |
| Uniprot ID | DMPK_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu426 |
Additional Info
| Post Translational Modifications | Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. |
| Function | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
| Protein Name | Myotonin-Protein KinaseMt-PkDm-KinaseDmkDm1 Protein KinaseDmpkMyotonic Dystrophy Protein Kinase |
| Database Links | Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideNucleus Outer MembraneMitochondrion Outer MembraneSarcoplasmic Reticulum MembraneCell MembraneCytoplasmCytosolLocalizes To Sarcoplasmic Reticulum Membranes Of CardiomyocytesIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Protein Names | Myotonin-Protein Kinase proteinMt-Pk proteinDm-Kinase proteinDmk proteinDm1 Protein Kinase proteinDmpk proteinMyotonic Dystrophy Protein Kinase proteinDMPK proteinDM1PK proteinMDPK protein |
Information sourced from Uniprot.org