| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, 200 mM Arginine, pH 7.4. Contact us for customized product form or formulation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | DLL3 |
| Gene ID: | 10683 |
| Uniprot ID: | DLL3_HUMAN |
| Immunogen: | Recombinant Human CD40L/CD154 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala27-Arg491) of human DLL3 (Accession #Q9NYJ7) fused with His at the N-terminus. |
| Immunogen Region: | Ala27-Arg491 |
| Immunogen Sequence: | AGVFELQIHSFGPGPGPGAP RSPCSARLPCRLFFRVCLKP GLSEEAAESPCALGAALSAR GPVYTEQPGAPAPDLPLPDG LLQVPFRDAWPGTFSFIIET WREELGDQIGGPAWSLLARV AGRRRLAAGGPWARDIQRAG AWELRFSYRARCEPPAVGTA CTRLCRPRSAPSRCGPGLRP CAPLEDECEAPLVCRAGCSP EHGFCEQPGECRCLEGWTGP LCTVPVSTSSCLSPRGPSS |
| Post Translational Modifications | Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. |
| Function | Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. |
| Protein Name | Delta-Like Protein 3Drosophila Delta Homolog 3Delta3 |
| Database Links | Reactome: R-HSA-9793380Reactome: R-HSA-9824272 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Delta-Like Protein 3 proteinDrosophila Delta Homolog 3 proteinDelta3 proteinDLL3 protein |
Information sourced from Uniprot.org