• Biotinylated Human DKK3 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
  • The purity of Biotinylated Human DKK3 is greater than 95% as determined by SEC-HPLC.

Human DKK3 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001554)

SKU:
STJP001554

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human DKK3-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: DKK3
Gene ID: 27122
Uniprot ID: DKK3_HUMAN
Immunogen Region: Pro23-Ile350
Immunogen: DNA sequence encoding Human DKK3 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications N- and O-glycosylated.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 3
Dickkopf-3
Dkk-3
Hdkk-3
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 3 protein
Dickkopf-3 protein
Dkk-3 protein
Hdkk-3 protein
DKK3 protein
REIC protein
UNQ258 protein
PRO295 protein

Information sourced from Uniprot.org

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