Human DKK2 protein (Recombinant) (N-His) (STJP006137)

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STJP006137
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DKK2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DKK2
Gene ID: 27123
Uniprot ID: DKK2_HUMAN
Immunogen Region: Lys34-Ile259
Immunogen: Homo sapiens (Human)
Post Translational Modifications May be proteolytically processed by a furin-like protease.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 2
Dickkopf-2
Dkk-2
Hdkk-2
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 2 protein
Dickkopf-2 protein
Dkk-2 protein
Hdkk-2 protein
DKK2 protein
UNQ682 protein
PRO1316 protein

Information sourced from Uniprot.org

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